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FTO

Frayling TM, Timpson NJ, Weedon MN et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood obesity. Science 316 :889-894

TCF7

Cauchi S, Nead KT, Gutierrez-Aguilar R et al. (2008) Effects of TCFL2 polymorphism on obesity in European populations.  Obesity 16: 476-482

Cauchi S, Meyre D, Dina C et al. (2006) Transcription factor TCFL2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55: 2903-2908

Kimber CH, Doney ASF, Pearson ER et al (2007) TCF7L2 in the Go-DARTS study: evidence of a gene dose effect on both diabetes susceptibility and control of glucose levels. Diabetologia 1-6

Melzer D, Murray A, Hurst AJ et al (2006) Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Medicine 4: 34
Vliet-Ostaptchouk JV, Sverdlov R, Zhernakova et al (2006) Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort. Diabetologia 50: 59-62

Weedon, MN (2007) The importance of TCF7L2 Diabet Med 24: 1062-1066
Wellcome Trust Case Control Consortium (2007) Genome-wide association of 14 000 cases of seven common diseases and 3000 shared controls. Nature 447: 661-678

GNB3

Casiglia E, Tikhonoff V, Caffi S et al. (2008) Effects of the C825T polymorphism of the GNB3 gene on body adiposity and blood pressure in fertile and menopausal women: a population-based study.

Danoviz ME, Pereira AC, Mill JG et al. (2006) Hypertension, obesity and GNB3 gene variants. Clin Exp Pharmacol Physiol 33: 248-252

Dishy V, Guota S, Landua R et al. (2003) G-protein beta-3 subunit 825C/T polymorphism is associated with weight gain during pregnancy. Pharmocogen 13: 241-242

Siffert W, Forster P, Jockel KH et al. (1999) Worldwide ethnic distribution of the G protein beta-3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African individuals. J Am Soc Nephrol 10: 1921-1030

NPY

Karvonen MK, Koulu M, Pesonen U et al (2000) Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birthweight and serum triglyceride concentration in preschool-aged children. J Clin Endocr Metab 85: 1455-1460

Karvonen MK, Pesonen U, Koulu M et al. (1998) Association of  leucine(7)–to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nature Med 4: 1434-1437

ADRB2

Castellano M, Rossi F, Giacche M et al. (2002)  β2 – adrenergic receptor gene polymorphism, age and cardiovascular phenotypes. Hypertension 41: 361-367

Dallongeville J, Helbecque N, Cottel D et al. (2003) The gly16-arg16 and gln27-glu27 polymorphisms of beta-2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocr Metab 88: 4862-4866

Kato N, Sugiyama T, Morita H et al. (2001) Association analysis of  β2 – adrenergic receptor polymorphisms with hypertension in Japanese. Hypertension 37: 286-292

Large V, Hellstrom L, Reynisdottir S et al. (1997) Human beta-2 adrenoreceptor gene polymorphism are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor funtion. J Clin Invest 100: 3005-3013

Lima JJ, Feng H, Duckworth L et al. (2007) Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations. Metabolism 56: 757-765

Pereira AC, Floriano MS, Gloria FA  et al. (2003)  β2 – adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population. Hypertension 42: 685-692

Wagoner LE, Craft LL, Singh B et al. (2000) Polymorphisms of the  β2 – adrenergic receptor determine exercise capacity in patients with heart failure. Circ Res 86: 834-840

 
ADRB2-16

Meirhaeghe A, Luan J, Selberg-Franks P et al. (2001) The effect of the gly16arg polymorphism of the beta-2-adrenergic receptor gene on on plasma free fatty acid levels is modulated by physical activity. J Clin Endocr Metab 86: 5881-5887

ADRB2-27

Corbalan MS, Marti A, Forga L et al. (2002) The 27Glu polymorphism of the beta-2 adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects .

Gonzalez Sanchez JL, Proenza AM, Martinez Larrad MT et al. (2003) The glutamine 27 glutamic acid polymorphism of the  β2 – adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain. Clin Endocr 59: 476-481

Hellstrom L, Large V, Reynisdottir S et al. (1999) The different effects if a Gln27Glu β2 – adrenoceptor gene polymorphism on obesity in males and in females. J Intern Med 245: 253-259

Kortner B, Wolf A, Wendt D et al. (1999) Lack of association between a human beta-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity. Int J Relat Metab Disord 23: 1099-1100

Yamada K, Ishiyama-Shigemoto S, Ichikawa F et al. (1999) Polymorphism in the 5'-leader cistron of the  β2 – adrenergic receptor gene associated with obesity and type 2 diabetes. J Clin Endocr Metab 84: 1754-1757

ADRB3

Fujisawa T, Ikegami H, Kawaguchi Y et al. (1998) Meta-analysis of the association of Trp64Arg polymorphism of  β3 – adrenergic receptor gene with body mass index. J Clin Endocrinol Metab 83: 2441-2444

Hao K, Peng S, Xing H et al. (2004) beta(3) Adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients. Obes Res 12: 125-130

Kurokawa N, Young EH, Oka Y (2008) The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44833 individuals. Int J Obes (online publication)

Zafarmand MH, van der Schouw YT, Grobbee DE et al. (2007) T64A polymorphism in β3- adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis. J Intern Med 263:79-89.

 

 
 
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